The 12th international symposium on “Large TPCs for low-energy rare event detection” will be held in Paris on the 15th-17th of December 2025. The purpose of the meeting is an extensive discussion of present and future projects using a large TPC for low-energy, low-background detection of rare events (low-energy neutrinos, double beta decay, dark matter, solar axions). There is an increasing number of experiments using or planning to use very large gaseous or liquid TPCs. A common feature of the detection scheme will be the measurement of the energy and direction of ion recoils. The search for